Hybrid Wireframe DNA Nanostructures with Scaffolded and Scaffold-Free Modules

The scaffolded DNA origami approach and the scaffold-free LEGO approach both demonstrate an extraordinary self-assembly capability for constructing all kinds of complex DNA nanostructures. Combining the construction elements of the two approaches, we introduce a hybrid framework to build wireframe structures in this study. A collection of two-dimensional (2D) and three-dimensional (3D) wireframe structures are presented to showcase the simple and versatile design. Our development reveals more of the ever-expanding design space of structural DNA nanotechnology.

Automated summary

The study introduces a hybrid framework to build wireframe structures, showcasing their simple and versatile design. By combining the construction elements of scaffolded DNA origami approach and scaffold-free LEGO approach, the design space of structural DNA nanotechnology is expanded.