Silver-Enabled General Radical Difluoromethylation Reaction with TMSCF2H

A silver-mediated oxidative difluoromethylation of styrenes and vinyl trifluoroborates with TMSCF2H is reported for the first time. This method enables direct and facile access to CF2H-alkenes from abundant alkenes with excellent functional-group compatibility. Moreover, this Ag/TMSCF2H protocol could further enable a series of radical difluoromethylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C-CF2H bonds.

Automated summary

This new method involves the reaction of TMSCF2H with styrenes and vinyl trifluoroborates to directly prepare CF2H-alkenes with excellent functional group compatibility. Additionally, this approach can be applied to a variety of substrates for radical difluoromethylation reactions, providing a versatile platform for constructing diverse C-CF2H bonds.