期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 9, 页码 4561-4565出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202013450
关键词
asymmetric catalysis; beta-lactams; copper; Kinugasa reaction; sulfur
资金
- Natural Science Foundation of China
- Natural Science Foundation of Shandong Province [21971149, ZR2019BB060, ZR2019ZD45]
- Fundamental Research Funds of Shandong University
A new method has been developed for the synthesis of sulfur-containing chiral beta-lactams with two consecutive stereogenic centers using copper(I)-catalyzed asymmetric, three-component interrupted Kinugasa reaction. The key lies in the interception of in situ formed chiral four membered copper(I) enolate intermediate with sulfur electrophiles, resulting in good yields and excellent diastereo- and enantioselectivity.
A copper(I)-catalyzed asymmetric, three-component interrupted Kinugasa reaction has been developed. Diverse chiral sulfur-containing chiral beta-lactams with two consecutive stereogenic centers were synthesized in one step from readily available starting materials in good yields and with excellent diastereo- and enantioselectivity. The key is the interception of in situ formed chiral four membered copper(I) enolate intermediate with sulfur electrophiles.
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