期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 12, 页码 6545-6552出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202014510
关键词
amino alcohols; asymmetric catalysis; palladium; stereodivergence; synergistic catalysis
资金
- National Natural Science Foundation of China [21871150, 22071118, 22001130]
- Fundamental Research Funds for Central University [63201049]
- China Postdoctoral Science Foundation [2019M660973]
The study presents a dual-metal catalyzed diastereodivergent coupling method for the synthesis of beta-amino alcohols with multiple stereoisomers, enabling the concise preparation of natural products such as mycestericins F and G.
Both syn- and anti-beta-amino alcohols are common structural motifs in natural products, drug molecules, chiral ligands and catalysts. However, the currently available methods for synthesizing these motifs are limited to generate only one diastereoisomer. Therefore, development of a unified method for stereoselective access to complementary diastereomers would be highly desirable. Herein, we report a method for dual-metal-catalyzed diastereodivergent coupling of alkoxyallenes with aldimine esters. By carefully selecting the two metals and appropriate chiral ligands, we could synthesize both syn- and anti-beta-amino alcohol motifs with high enantioselectivity and diastereoselectivity from the same set of starting materials. Furthermore, stereodivergent syntheses of all four stereoisomers of beta-amino alcohols could be achieved. We demonstrated the synthetic utility of this method by concisely synthesizing two beta-amino alcohol natural products, mycestericins F and G.
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