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Review
Andrology
Manish Kuchakulla et al.
Summary: Spermatogenesis is a complex process involving multiple regulatory elements and steps, essential for maintaining and promoting male fertility. Reduced sperm DNA integrity can negatively impact fertility, with sources of DNA damage including replication errors and fragmentation due to various causes like apoptosis and oxidative stress. Research also covers DNA repair mechanisms in spermatozoon.
Review
Andrology
Saradha Baskaran et al.
Summary: ROS play a crucial role in male fertility by regulating various physiological processes and signaling pathways, but oxidative stress resulting from excessive ROS can damage sperm integrity and function.
Review
Andrology
Marwan Ali et al.
Summary: Oxidative stress is linked to male infertility, and the use of antioxidants may improve sperm health, but there is still controversy over the effectiveness of these therapies.
Review
Andrology
Vaithinathan Selvaraju et al.
Summary: The rapid industrialisation leading to excessive discharge of synthetic substances into the environment has been correlated with male infertility and decreasing sperm quality. Multiple studies have shown that environmental contaminants can affect spermatogenesis, steroidogenesis, Sertoli cells, blood-testis barrier, epididymis, and sperm functions.
