DNA Nanomachines for Identifying Cancer Biomarkers in Body Fluids and Cells

Identifying molecular biomarkers promises to significantly improve the accuracy in cancer diagnosis at its early stage. DNA nanomachines, which are designable and switchable nanostructures made of DNA, show broad potential to detect tumor biomarkers with noninvasive, inexpensive, highly sensitive, and highly specific advantages. This Feature summarizes the recent DNA nanomachine-based platforms for the early detection of cancer biomarkers, both from body fluids and in cells.

Automated summary

DNA nanomachines, designable and switchable nanostructures made of DNA, have great potential for early detection of cancer biomarkers with advantages of noninvasiveness, affordability, high sensitivity, and high specificity. This summary highlights recent DNA nanomachine-based platforms for detecting cancer biomarkers, both from body fluids and in cells.