期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 21, 期 6, 页码 2018-2024出版社
WILEY
DOI: 10.1111/ajt.16439
关键词
clinical decision-making; clinical research / practice; complication: medical / metabolic; geriatrics; immunobiology; lung biology; lung transplantation / pulmonology; recipient selection; risk assessment / risk stratification; translational research / science
资金
- National Institute on Aging [AG055879-01]
- National Institutes of Health [K23HL128859, R01HL151552]
- Veterans Affairs Office of Research and Development [CX002011]
Older and frailer lung transplant candidates are at increased risk for mortality. Evaluation of elderly and frail candidates is essential, as frailty is commonly associated with adverse outcomes in lung transplantation.
Many lung transplant candidates and recipients are older and frailer compared to previous eras. Older patients are at increased risk for pre- and posttransplant mortality, but this risk is not explained by numerical age alone. This manuscript represents the product of the American Society of Transplantation (AST) conference on frailty. Experts in the field reviewed the latest published research on assessment of elderly and frail lung transplant candidates. Physical frailty, often defined as slowness, weakness, low physical activity, shrinking, and exhaustion, and frailty evaluation is an important tool for evaluation of age-associated dysfunction. Another approach is assessment by cumulative deficits, and both types of frailty are common in lung transplant candidates. Frailty is associated with death or delisting before transplant, and may be associated with posttransplant mortality. Sarcopenia, cognitive dysfunction, depression, and nutrition are other important components for patient evaluation. Aging-associated inflammation, telomere dysfunction, and adaptive immune system senescence may also contribute to frailty. Developing tools for frailty assessment and interventions holds promise for improving patient outcomes before and after lung transplantation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据