The complex role of prostaglandin E-2-EP receptor signaling in wound healing

Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E-2 (PGE(2)) being the most complex and exhibiting the most diverse physiological outputs. PGE(2) signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE(2) and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.