期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 320, 期 2, 页码 H826-H837出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00608.2020
关键词
action potential model; spiral wave breakup; transient outward potassium current; ventricular arrhythmias
资金
- National Institutes of Health [R01 HL139829, R01 HL134709, F30 HL140864]
- Zhejiang Province Commonweal Projects [LGF18A050001]
- China Scholarship Council [201708330401]
This study conducted computer simulations on five ventricular action potential models and found that the transient outward potassium current (I-to) plays a key role in promoting spiral wave breakup. The absence of I-to can prevent spiral wave breakup, but increasing its maximum conductance can promote it. This observation has implications for understanding spiral wave dynamics in real hearts and improving action potential models.
Spiral wave reentry as a mechanism of lethal ventricular arrhythmias has been widely demonstrated in animal experiments and recordings from human hearts. It has been shown that in structurally normal hearts spiral waves are unstable, breaking up into multiple wavelets via dynamical instabilities. However, many of the second-generation action potential models give rise only to stable spiral waves, raising issues regarding the underlying mechanisms of spiral wave breakup. In this study, we carried out computer simulations of two-dimensional homogeneous tissues using five ventricular action potential models. We show that the transient outward potassium current (I-to), although it is not required, plays a key role in promoting spiral wave breakup in all five models. As the maximum conductance of I-to increases, it first promotes spiral wave breakup and then stabilizes the spiral waves. In the absence of I-to, speeding up the L-type calcium kinetics can prevent spiral wave breakup, however, with the same speedup kinetics, spiral wave breakup can be promoted by increasing I-to. Increasing I-to promotes single-cell dynamical instabilities, including action potential duration alternans and chaos, and increasing 6, further suppresses these action potential dynamics. These cellular properties agree with the observation that increasing I-to first promotes spiral wave breakup and then stabilizes spiral waves in tissue. Implications of our observations to spiral wave dynamics in the real hearts and action potential model improvements are discussed. NEW & NOTEWORTHY Spiral wave breakup manifesting as multiple wavelets is a mechanism of ventricular fibrillation. It has been known that spiral wave breakup in cardiac tissue can be caused by a steeply sloped action potential duration restitution curve, a property mainly determined by the recovery of L-type calcium current. Here, we show that the transient outward potassium current (I-to) is another current that plays a key role in spiral wave breakup, that is, spiral waves can be stable for low and high maximum I-to conductance but breakup occurs for intermediate maximum I-to conductance. Since I-to is present in normal hearts of many species and required for Brugada syndrome, it may play an important role in the spiral wave stability and arrhythmogenesis under both normal condition and Brugada syndrome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据