First reported outbreak of the emerging pathogen Candida auris in Canada

Background: Candida auris was first described in Japan in 2009 and has since been detected in over 40 countries. The yeast is concerning for multiple reasons, primarily: (1) challenges with accurate iden-tification; (2) reported multidrug resistance; (3) published mortality rates of 30%-60%; and (4) persis-tence in the environment associated with human transmission. We report the emergence of a healthcare-associated cluster in the Greater Vancouver area in 2018 and describe the measures imple-mented to contain its transmission. Methods: Cases were identified through passive and ring surveillance of affected wards. Positive isolates were sent to provincial and national reference laboratories for confirmation and genomic characterization. Extensive infection control measures were implemented immediately after the initial case was identified. Results: Four cases were identified during the outbreak. In a 4-month period, over 700 swabs were collected in order to screen 180 contacts. Whole genome sequencing concluded that all isolates clustered together and belonged to the South Asian clade. No isolates harbored FKS gene mutations associated with resistance to echinocandins. Infection control measures, including surveillance, education, cleaning and/or disinfection, patient cohorting, isolation, and hand hygiene, effectively contained the outbreak; it was declared over within 2 months. Conclusions: The spread of C auris in healthcare facilities has not spared Canadian institutions. Our expe-rience demonstrates that strict infection control measures combined with microbiological screening can effectively halt transmission in healthcare centers. The necessity of active prospective screening remains unclear. Crown Copyright (c) 2021 Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc. All rights reserved.

Automated summary

The healthcare-associated cluster of Candida auris in the Greater Vancouver area was effectively contained through strict infection control measures and microbiological screening, demonstrating the importance of proactive measures in preventing transmission in healthcare settings.