期刊
AGING-US
卷 13, 期 1, 页码 1-15出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.202463
关键词
SARS-CoV-2; COVID-19; telomeres; aging
资金
- Spanish Ministry of Science and Innovation [SAF2017-82623-R, SAF2015-72455-EXP]
- Comunidad de Madrid Project [B2017/BMD-3770]
- World Cancer Research (WCR) Project [16-1177]
- Fundacion Botin (Spain)
- CONACYT-Mexico
Shorter telomeres are associated with increased severity of COVID-19, particularly in older patients. This suggests that molecular pathways related to aging play a role in the disease's progression.
The incidence of severe manifestations of COVID-19 increases with age with older patients showing the highest mortality, suggesting that molecular pathways underlying aging contribute to the severity of COVID-19. One mechanism of aging is the progressive shortening of telomeres, which are protective structures at chromosome ends. Critically short telomeres impair the regenerative capacity of tissues and trigger loss of tissue homeostasis and disease. The SARS-CoV-2 virus infects many different cell types, forcing cell turn-over and regeneration to maintain tissue homeostasis. We hypothesize that presence of short telomeres in older patients limits the tissue response to SARS-CoV-2 infection. We measure telomere length in peripheral blood lymphocytes COVID-19 patients with ages between 29 and 85 years-old. We find that shorter telomeres are associated to increased severity of the disease. Individuals within the lower percentiles of telomere length and higher percentiles of short telomeres have higher risk of developing severe COVID-19 pathologies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据