4.6 Article

Shorter telomere lengths in patients with severe COVID-19 disease

期刊

AGING-US
卷 13, 期 1, 页码 1-15

出版社

IMPACT JOURNALS LLC
DOI: 10.18632/aging.202463

关键词

SARS-CoV-2; COVID-19; telomeres; aging

资金

  1. Spanish Ministry of Science and Innovation [SAF2017-82623-R, SAF2015-72455-EXP]
  2. Comunidad de Madrid Project [B2017/BMD-3770]
  3. World Cancer Research (WCR) Project [16-1177]
  4. Fundacion Botin (Spain)
  5. CONACYT-Mexico

向作者/读者索取更多资源

Shorter telomeres are associated with increased severity of COVID-19, particularly in older patients. This suggests that molecular pathways related to aging play a role in the disease's progression.
The incidence of severe manifestations of COVID-19 increases with age with older patients showing the highest mortality, suggesting that molecular pathways underlying aging contribute to the severity of COVID-19. One mechanism of aging is the progressive shortening of telomeres, which are protective structures at chromosome ends. Critically short telomeres impair the regenerative capacity of tissues and trigger loss of tissue homeostasis and disease. The SARS-CoV-2 virus infects many different cell types, forcing cell turn-over and regeneration to maintain tissue homeostasis. We hypothesize that presence of short telomeres in older patients limits the tissue response to SARS-CoV-2 infection. We measure telomere length in peripheral blood lymphocytes COVID-19 patients with ages between 29 and 85 years-old. We find that shorter telomeres are associated to increased severity of the disease. Individuals within the lower percentiles of telomere length and higher percentiles of short telomeres have higher risk of developing severe COVID-19 pathologies.

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