4.4 Review

Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective

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Summary: Myoepithelial carcinoma of salivary glands, including the clear cell variant, is aggressive with unknown genetic features. EWSR1 rearrangements were found in some cases, but without EWSR1 fusion transcripts.PLAG1 fusions, including LIFR-PLAG1 and CTNNB1-PLAG1, are frequent in EWSR1-FISH positive CCMCs. EWSR1 abnormalities without fusion may have a minor oncologic effect.

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