Sulfoximines with α-Ketoester Functionalities at Nitrogen from Cyanoacetates and Air

Sulfoximines with nitrogen-bound alpha-ketoester units are efficiently prepared by an operationally simple one-pot reaction sequence in air starting from methoxy(mesyloxy)iodobenzene, NH-sulfoximines, and cyanoacetates. Key of the process is the in-situ formation of hypervalent iodine reagents, which serve as electrophilic sulfoximidoyl sources.

Automated summary

This study efficiently prepares sulfoximines with nitrogen-bound alpha-ketoester units in air using a one-pot reaction sequence, with the key step being the in-situ formation of hypervalent iodine reagents serving as electrophilic sulfoximidoyl sources.