P(III)-Mediated Cascade C-N/C-S Bond Formation: A Protocol towards the Synthesis of N,S-Heterocycles and Spiro Compounds

A P(III)-mediated entry towards construction of C-N/C-S bond has been devised. The developed heterocyclization method was exercised for the synthesis of a diverse range of N,S-heterocycles and related spiro molecules. P(NMe2)(3) revealed the maximum efficacies under the aerobic reaction conditions and a spectrum of bis-nucleophiles, and isothiocyanates were tolerated well to serve the access of manifold immense molecules.

Automated summary

A P(III)-mediated method for constructing C-N/C-S bonds has been developed, allowing for the synthesis of a diverse range of N,S-heterocycles and spiro molecules. P(NMe2)(3) showed high efficacy under aerobic conditions, tolerating a variety of bis-nucleophiles and isothiocyanates.