期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 363, 期 8, 页码 2117-2123出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202001369
关键词
3-Methyleneindolinones; Amination; Cyclization; N-(2-iodophenyl)propiolamides; N-hydroxybenzamides
资金
- National Natural Science Foundation of China [21772001]
- Anhui Provincial Natural Science Foundation [1808085MB41]
- andCultivation Project for University Outstanding Talents of Anhui Province
A cascade intramolecular 5-exo-dig cyclization of N-(2-iodophenyl)propiolamides and sequential amination/etherification protocol has been developed for the synthesis of amino- and phenoxy-substituted 3-methyleneindolinones using inexpensive Pd(PPh3)(4) as catalyst. The protocol allows for the assembly of oxindole cores with moderate functional group tolerance, providing a broad spectrum of products with diverse substituents in good to excellent yields.
An cascade intramolecular 5-exo-dig cyclization of N-(2-iodophenyl)propiolamides and sequential amination/etherification (with N-hydroxybenzamides, phenyl hydroxycarbamate) protocol for the synthesis of amino- and phenoxy-substituted 3-methyleneindolinones using unexpensive Pd(PPh3)(4) as catalyst has been developed. The protocol enables the assembly of structurally important oxindole cores featuring moderate functional group tolerance (particularly the halo group), affording a broad spectrum of products with diverse substituents in good to excellent yields.
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