Cross-Coupling Reactions of Aryl Halides with Primary and Secondary Aliphatic Alcohols Catalyzed by an O,N,N-Coordinated Nickel Complex

A synthesis of alkyl aryl ethers was achieved via the cross-coupling of aryl halides with primary and secondary aliphatic alcohols catalyzed by a bench-stable nickel complex supported by a monoanionic O,N,N-tridentate ligand. This nickel-catalyzed reaction proceeds smoothly in the absence of a phosphine ligand, affording alkyl aryl ethers in moderate to good yields.

Automated summary

A nickel-catalyzed cross-coupling reaction between aryl halides and primary or secondary aliphatic alcohols has been achieved using a bench-stable nickel complex supported by a monoanionic O,N,N-tridentate ligand. The reaction proceeds smoothly without the need for a phosphine ligand, giving moderate to good yields of alkyl aryl ethers.