期刊
ADVANCED MATERIALS
卷 33, 期 8, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202006932
关键词
DNA nanoelectronics; guanine octuplex (G8-DNA); guanine quadruplex (G4-DNA)
类别
资金
- Israel Science Foundation (ISF) [1589/14]
- ISF-NSFC [2556/17]
- Ministry of Science & Technology, Israel [3-16840]
- Minerva Centre for bio-hybrid complex systems
The guanine octuplex (G8)-DNA is a novel DNA structure with enhanced stiffness, mechanical and thermodynamic stability compared to its parent G4-DNA, making it a compelling candidate for molecular nanoelectronics.
Guanine quadruplex (G4)-DNA structures have sparked the interest of many scientists due to their important biological roles and their potential use in molecular nanoelectronics and nanotechnology. The high guanine content in G4-DNA endows it with mechanical stability, robustness, and improved charge transport properties-attractive attributes for a molecular nanowire. The self-driven formation of a novel G4-DNA-based nanostructure, coined guanine octuplex (G8)-DNA, is reported herein. Atomic force microscopy and scanning tunneling microscopy characterization of this molecule reveal its organized coiled-coil structure, which is found to be stable under different temperatures and surrounding conditions. G8-DNA exhibits enhanced stiffness, mechanical and thermodynamic stability when compared to its parent G4-DNA. These, along with its high guanine content, make G8-DNA a compelling new molecule, and a highly prospective candidate for molecular nanoelectronics.
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