期刊
ADVANCED MATERIALS
卷 33, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202003458
关键词
immunotherapies; organic nanoparticles; photothermal therapies; second near-infrared windows
类别
资金
- Nanyang Technological University [NTU-SUG: M4081627.120]
- Singapore Ministry of Education, Academic Research Fund Tier 1 [2017T1-002-134, 2019-T1-002-045]
- Singapore Ministry of Education, Academic Research Fund Tier 2 [MOE2018-T2-2-042]
This study introduces a novel semiconducting polymer nanoadjuvant for second NIR-II photothermal immunotherapy, which effectively inhibits tumor growth and eliminates metastasis through a combination of photothermal conversion and TLR agonist release.
Immunotherapy has offered new treatment options for cancer; however, the therapeutic benefits are often modest and desired to be improved. A semiconducting polymer nanoadjuvant (SPNIIR) with a photothermally triggered cargo release for second near-infrared (NIR-II) photothermal immunotherapy is reported here. SPNIIR consists of a semiconducting polymer nanoparticle core as an NIR-II photothermal converter, which is doped with a toll-like receptor (TLR) agonist as an immunotherapy adjuvant and coated with a thermally responsive lipid shell. Upon NIR-II photoirradiation, SPNIIR effectively generates heat not only to ablate tumors and induce immunogenic cell death (ICD), but also to melt the lipid layers for on-demand release of the TLR agonist. The combination of ICD and activation of TLR7/TLR8 enhances the maturation of dendritic cells, which amplifies anti-tumor immune responses. Thus, a single treatment of SPNIIR-mediated NIR-II photothermal immunotherapy effectively inhibits growth of both primary and distant tumors and eliminates lung metastasis in a murine mouse model. This study thus provides a remote-controlled smart delivery system to synergize photomedicine with immunotherapy for enhanced cancer treatment.
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