期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 10, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202005709
关键词
bioimaging; DNA; gold nanoparticles; self‐ assembly; theranostics
类别
资金
- National Natural Science Foundation of China [21635002, 21874024]
- Program for Changjiang Scholars and the Innovative Research Team in University [IRT15R11]
- Health and Education Commission of Fujian Province [2019-WJ-20]
Plasmonic gold nanocrystals exhibit unique optical enhancement, catalytic activity, and photothermal properties, and when combined with DNA technology, novel functional Au nanomaterials can be created for biosensing, imaging, drug delivery, and therapy applications.
Plasmonic gold nanocrystal represents plasmonic metal nanomaterials, and has a variety of unique and beneficial properties, such as optical signal enhancement, catalytic activity, and photothermal properties tuned by local temperature, which are useful in physical, chemical, and biological applications. In addition, the inherent properties of predictable programmability, sequence specificity, and structural plasticity provide DNA nanostructures with precise controllability, spatial addressability, and targeting recognition, serving as ideal ligands to link or position building blocks during the self-assembly process. Self-assembly is a common technique for the organization of prefabricated and discrete nanoparticle blocks for the construction of extremely sophisticated nanocomposites. To this end, the integration of DNA nanotechnology with Au nanomaterials, followed by assembly of DNA-functionalized Au nanomaterials can form novel functional Au nanomaterials that are difficult to obtain through conventional methods. Here, recent progress in DNA-assembled Au nanostructures of various shapes is summarized, and their functions are discussed. The fabrication strategies that employ DNA for the self-assembly of Au nanostructures, including dimers, tetramers, satellites, nanochains, and other nanostructures with more complex geometric configurations are first described. Then, the characteristic optical properties and applications of biosensing, bioimaging, drug delivery, and therapy are discussed. Finally, the remaining challenges and prospects are elucidated.
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