Synthesis of MoSe2/CoSe2 Nanosheets for NIR-Enhanced Chemodynamic Therapy via Synergistic In-Situ H2O2 Production and Activation

Currently, the limited intratumoral H2O2 level restricts the development of chemodynamic therapy (CDT). Herein, MoSe2/CoSe2@PEG nanosheets are prepared to reveal NIR-photocatalytic H2O2 generation to insure the intracellular H2O2 supplement. The formation mechanism is investigated, showing the dissolved O-2 and photo-excited electrons to determine H2O2 production via sequential single-electron transfer process. The experimental data and density functional theory calculation further display their typical-II heterostructure, which possesses the effective charge separation and nearly four times H2O2 generation than MoSe2@PEG. In addition, the nanocomposites also reveal the peroxidase/catalase activity, making the in-situ H2O2 activation and center dot OH generation. And, the O-2 production derived from catalase-mimic activity not only relieves hypoxia but also offers the source for H2O2 production. Because of the decreased resistance for charge transfer, MoSe2/CoSe2@PEGs also reveal more than three times enzyme-activity for MoSe2@PEG. With the narrow band gap and high NIR-harvest, MoSe2/CoSe2@PEG exhibits the great photothermal converting ability (62.5%). MoSe2/CoSe2@PEG reveals the novel biodegradation, and most of them can be eliminated via urine and feces within 2 weeks. Here, the computed tomography/magnetic resonance imaging/photothermal imaging and the synergistic photothermal therapy/CDT treatments further make sure potential application on anticancer.

Automated summary

The MoSe2/CoSe2@PEG nanosheets can generate H2O2 in tumors, elevate the intracellular H2O2 level, and have great potential in anticancer applications.