期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 171, 期 -, 页码 94-107出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.01.009
关键词
Photochemistry; Photoactivated; Light-mediated delivery; In vivo drug delivery; Photodegradable hydrogels; Photoresponsive nanoparticles; Prodrugs; Dual-action; Photoswitches
资金
- Faculty Early Career Development CAREER Award [DMR 1652141]
- National Science Foundation [DMR 1807398]
- Maximizing Investigators' Research Award from the National Institutes of Health [R35GM138036]
- Washington Research Foundation
This article discusses the unique power of light as a tool for controlling molecular events in biology and highlights recent innovations in photosensitive drug delivery. It also points out future opportunities to engineer and exploit light-responsive technologies in the clinical setting.
Light is a uniquely powerful tool for controlling molecular events in biology. No other external input (e.g., heat, ultrasound, magnetic field) can be so tightly focused or so highly regulated as a clinical laser. Drug delivery vehicles that can be photonically activated have been developed across many platforms, from the simplest caging of therapeutics in a prodrug form, to more complex micelles and circulating liposomes that improve drug uptake and efficacy, to large-scale hydrogel platforms that can be used to protect and deliver macromolecular agents including full-length proteins. In this Review, we discuss recent innovations in photosensitive drug delivery and highlight future opportunities to engineer and exploit such light-responsive technologies in the clinical setting. (c) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据