期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 170, 期 -, 页码 261-280出版社
ELSEVIER
DOI: 10.1016/j.addr.2020.12.016
关键词
Antibiotic resistance; Antimicrobial peptides; Membrane-active antimicrobial mechanism; Clinical translation; Radially amphiphilic conformation; Infection-responsive peptides; Nano-antimicrobials; Small synthetic mimics of antimicrobial pep-tides; Combination therapy
资金
- National Science Foundation [CHE 1709820]
AMPs and SMAMPs have attracted significant enthusiasm in the past thirty years due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. Despite challenges inherent to current design strategies slowing down the clinical translational development of AMPs and SMAMPs, these challenges have triggered efforts to redesign and repurpose AMPs.
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have sounded a piercing alarm for the need of new effective antimicrobial agents to guard public health. Among different types of candidates, antimicrobial peptides (AMPs) and the synthetic mimics of AMPs (SMAMPs) have attracted signifi-cant enthusiasm in the past thirty years, due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. The extensive research has brought many drug candidates into clinical and pre-clinical development. Despite tremendous progresses have been made, several major challenges inherent to current design strategies have slowed down the clinical translational development of AMPs and SMAMPs. However, these challenges also triggered many efforts to redesign and repurpose AMPs. In this review, we will first give an overview on AMPs and their synthetic mimics, and then discuss the current status of their clinical translation. Finally, the recent advances in redesign and repurposing AMPs and SMAMPs are highlighted. (c) 2020 Published by Elsevier B.V.
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