期刊
ACTA NEUROPATHOLOGICA
卷 141, 期 3, 页码 415-429出版社
SPRINGER
DOI: 10.1007/s00401-020-02258-z
关键词
Multiple sclerosis; Neurodegeneration; Interneurons; Myelin; Synapses
资金
- Medical Research Council [16/ES/0084]
- MS Society UK Centre
- MS Society UK
- UK Dementia Research Institute from Alzheimer's Research UK
- Alzheimer's Society
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [681181]
- Deutsche Forschungsgemeinschaft (DFG) [320041273]
- Simons Foundation Autism Research Initiative [529085]
- Patrick Wild Centre
- MRC [MR/P016022/1, MR/K014137/1, MR/P006213/1, UKDRI-4004] Funding Source: UKRI
Neurodegeneration in multiple sclerosis may affect specific neuronal components early on, and could be a result of demyelination.
In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system, neurodegeneration is detected early in the disease course and is associated with the long-term disability of patients. Neurodegeneration is linked to both inflammation and demyelination, but its exact cause remains unknown. This gap in knowledge contributes to the current lack of treatments for the neurodegenerative phase of MS. Here we ask if neurodegeneration in MS affects specific neuronal components and if it is the result of demyelination. Neuropathological examination of secondary progressive MS motor cortices revealed a selective vulnerability of inhibitory interneurons in MS. The generation of a rodent model of focal subpial cortical demyelination reproduces this selective neurodegeneration providing a new preclinical model for the study of neuroprotective treatments.
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