期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 53, 期 2, 页码 131-139出版社
SCIENCE PRESS
DOI: 10.1093/abbs/gmaa155
关键词
NLRP3 inflammasome activation; potassium ion; chloride ion; calcium ion; magnesium ion; manganese ion; zinc ion
资金
- National Natural Science Foundation of China [81873064, 81773965]
The activation of the NLRP3 inflammasome involves a variety of activators inducing changes in ion concentrations, mitochondrial dysfunction, and lysosomal disruption, potentially acting through a common mechanism of coordinated intracellular ion flux.
The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome can be induced by a wide spectrum of activators. This is unlikely achieved by the binding of different activators directly to the NLRP3 protein itself, as the activators found so far show different forms of chemical structures. Previous studies have shown that these activators can induce potassium ion (K+) and chloride ion (Cl-) efflux, calcium (Ca2+) and other ion mobilization, mitochondrial dysfunction, and lysosomal disruption, all of which are believed to cause NLRP3 inflammasome activation; how these events are induced by the activators and how they coordinate with each other in inducing the NLRP3 inflammasome activation are not fully understood. Increasing evidence suggests that the coordinated change of intracellular ion concentrations may be a common mechanism for the NLRP3 activation by different activators. In this mini-review, we present a brief summary of the current knowledge about how different ionic flows (including K+, sodium ion, Ca2+, magnesium ion, manganese ion, zinc ion, iron ion, and Cl-) are involved in regulating the NLRP3 inflammasome activation in macrophages.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据