期刊
ACS NANO
卷 15, 期 1, 页码 979-988出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c07655
关键词
chirality; cobalt oxide nanoparticle; Tyr-Tyr-Cys; peptide ligand; magnetic circular dichroism; NMR
类别
资金
- Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2017M3D1A1039377]
- KIST-SNU Joint Research Lab project under the KIST Institutional Program - Korean government (Ministry of Science, ICT & Future Planning) [2 V06170]
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2017R1A2B3012003]
- LG Display under the LGD-SNU Incubation Program
- Institute of Engineering Research, Research Institute of Advanced Materials (RIAM)
- Soft Foundry at Seoul National University
- National Research Foundation of Korea [2019H1A2A1077150] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Chiral inorganic nanomaterials, particularly chiral cobalt oxide nanoparticles synthesized with L- and D-Tyr-Tyr-Cys ligands, have been highlighted for their catalytic activity and biocompatibility. The conformation of the Tyr-Tyr-Cys peptide on the nanoparticle surfaces was identified by 2D NMR spectroscopy analysis, and the sequence effect of Tyr-Tyr-Cys developing chiral nanoparticles was analyzed. The role of the thiol group and carboxyl group of the Tyr-Tyr-Cys ligand in chirality evolution was demonstrated, with the circular dichroism responses being dramatically modulated under an external magnetic field due to the magnetic properties of chiral cobalt oxide nanoparticles.
Chiral inorganic nanomaterials have revealed opportunities in various fields owing to their strong light-matter interactions. In particular, chiral metal oxide nanomaterials that can control light and biochemical reactions have been highlighted due to their catalytic activity and biocompatibility. In this study, we present the synthesis of chiral cobalt oxide nanoparticles with a g-factor of 0.01 in the UV-visible region using L- and D-Tyr-Tyr-Cys ligands. The conformation of the Tyr-Tyr-Cys peptide on the nanoparticle surfaces was identified by 2D NMR spectroscopy analysis. In addition, the sequence effect of Tyr-Tyr-Cys developing chiral nanoparticles was analyzed. The revealed peptide structure, along with the experimental results, demonstrate the important role of the thiol group and carboxyl group of the Tyr-Tyr-Cys ligand in chirality evolution. Importantly, due to the magnetic properties of chiral cobalt oxide nanoparticles and their strong absorption in the UV region, the circular dichroism (CD) responses can be dramatically modulated under an external magnetic field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据