4.8 Article

Environmental Control of Amyloid Polymorphism by Modulation of Hydrodynamic Stress

期刊

ACS NANO
卷 15, 期 1, 页码 944-953

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c07570

关键词

protein aggregation; amyloid polymorphism; environmental control; air-water interface; hydrodynamic flow

资金

  1. Swiss National Science Foundation [200021_162767]
  2. Darwin College

向作者/读者索取更多资源

This study reveals a correlation between environmental stress and amyloid polymorphism, with high stress conditions favoring the formation of homogeneous amyloid fibrils.
The phenomenon of amyloid polymorphism is a key feature of protein aggregation. Unravelling this phenomenon is of great significance for understanding the underlying molecular mechanisms associated with neurodegenerative diseases and for the development of amyloid-based functional biomaterials. However, the understanding of the molecular origins and the physicochemical factors modulating amyloid polymorphs remains challenging. Herein, we demonstrate an association between amyloid polymorphism and environmental stress in solution, induced by an air/water interface in motion. Our results reveal that low-stress environments produce heterogeneous amyloid polymorphs, including twisted, helical, and rod-like fibrils, whereas high-stress conditions generate only homogeneous rod-like fibrils. Moreover, high environmental stress converts twisted fibrils into rodlike fibrils both in-pathway and after the completion of mature amyloid formation. These results enrich our understanding of the environmental origin of polymorphism of pathological amyloids and shed light on the potential of environmentally controlled fabrication of homogeneous amyloid biomaterials for biotechnological applications.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据