期刊
ACS NANO
卷 14, 期 12, 页码 17365-17375出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c07495
关键词
DNA nanostructure; octahedron; hierarchical self-assembly; cancer imaging; targeted cancer therapy
类别
资金
- NSFC [21827811, 91753109]
- National Key R&D Program of China [2018YFA0902300]
- Huxiang Young Talent Program from Hunan Province [2019RS1922]
- Key Research and Development Project of Hunan Province [2019NK2101]
- China Postdoctoral Science Foundation [BX20190111, 2020M682535]
- Hunan Provincial Innovation Foundation for Postgraduate [CX20200399]
Though small-molecule drugs play a crucial role in cancer treatment, intrinsic issues such as poor solubility and systematic toxicity have considerably mitigated their anticancer functions and caused unwanted side effects. To achieve satisfying therapeutic efficiency, it is essential to develop innovative targeting systems for precise and efficient delivery of anticancer drugs. In this work, a hierarchical self-assembly strategy was applied to fabricate a core-shell nanoarchitecture composed of a DNA octahedral wireframe and chemodrug-functionalized Sgc8c aptamer. The integrated enhanced permeability and retention effect of the DNA nanostructure and active targeting ability of the Sgc8c aptamer allowed the highly selective chemodrug delivery and in vivo efficient imaging and treatment. The advantage of our multifunctional nanostructure was further highlighted by its impressive serum stability, excellent accumulation ability, deep penetration capability, significantly improved therapeutic efficacy, and favorable biosafety. This study showed promising potential of such a core-shell DNA nanoarchitecture in precise drug loading control, drug delivery, and personal medicine.
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