期刊
ACS NANO
卷 15, 期 1, 页码 1086-1099出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c08045
关键词
MXene; medical implant; biofilm; thermotherapy; tissue regeneration
类别
资金
- National Natural Science Foundation of China [52002391, 81772309, 81974324]
- China Postdoctoral Science Foundation [2019M660098]
- Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures [SKL201906]
2D niobium carbide (Nb2C) MXene titanium plate Nb2C@TP)-based clinical implant offers practical multimodal anti-infection functions, capable of destroying biofilms for direct bacteria elimination through down-regulating bacterial energy metabolism pathways, suppressing biofilm formation, and enhancing biofilm detachment via activating the accessory gene regulator.
Incurable bacterial infections, impenetrable microbial biofilm, and irreversible antibiotic resistance are among the most dangerous threats for humans. With few effective strategies available in antimicrobial and antibiofilm development, innovative methodologies inspired by the advances in other fields such as nanomedicine are becoming more and more attractive to realize innovative antibacterial agents. Herein, a 2D niobium carbide (Nb2C) MXene titanium plate Nb2C@TP)-based clinical implant with practical multimodal anti-infection functions was developed. Such emerging modes are capable of destroying biofilms for direct bacteria elimination through down-regulating bacterial energy metabolism pathways, suppressing biofilm formation, and enhancing as-formed biofilm detachment via an activating accessory gene regulator. Another intriguing feature of this nanomedicine is the sensitization ability toward bacteria via photothermal transduction, which reduces the temperature necessary for bacteria eradication and mitigates possible normal tissue damage. Moreover, the Nb2C@TP medical implant is able to alleviate proinflammatory responses by scavenging excessive reactive oxygen species in infectious microenvironments, benefiting angiogenesis and tissue remodeling.
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