期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 52, 页码 57782-57797出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c18948
关键词
injectable hydrogel; multi-cross-linked double-network; adhesiveness; self-healing; wound healing
资金
- National Key Research and Development Program of China [2017YFC1103501]
- National Natural Science Foundation of China [31871000, 31771067, 81621003]
- Key R&D Plan of Jiangsu Province [BE2018010-3]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
The development of natural polymer-based hydrogels, combining outstanding injectability, self-healing, and tissue adhesion, with mechanical performance, able to facilitate full-thickness skin wound healing, remains challenging. We have developed an injectable micellar hydrogel (AF127/HA-ADH/OHA-Dop) with outstanding adhesive and self-healing properties able to accelerate full-thickness skin wound healing. Dopamine-functionalized oxidized hyaluronic acid (OHA-Dop), adipic acid dihydrazide-modified HA (HA-ADH), and aldehyde-terminated Pluronic F127 (AF127) were employed as polymer backbones. They were cross-linked in situ using Schiff base dynamic covalent bonds (AF127 micelle/HA-ADH network and HA-ADH/OHA-Dop network), hydrogen bonding, and pi-pi stacking interactions. The resulting multicross-linked double-network design forms a micellar hydrogel. The unique multicross-linked double-network structure endows the hydrogel with both improved injection abilities and mechanical performance while self-healing faster than single-network hydrogels. Inspired by mussel foot adhesive protein, OHA-Dop mimics the catechol groups seen in mussel proteins, endowing hydrogels with robust adhesion properties. We also demonstrate the potential of our hydrogels to accelerate full-thickness cutaneous wound closure and improve skin regeneration with reduced scarring. We anticipate that our hydrogel platform based on a novel multicross-linked double-network design will transform the future development of multifunctional wound dressings.
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