4.8 Article

Voltage-Switchable Biosensor with Gold Nanoparticles on TiO2 Nanotubes Decorated with CdS Quantum Dots for the Detection of Cholesterol and H2O2

期刊

ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 3, 页码 3653-3668

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c19979

关键词

anodization; titanium oxide nanotubes; cadmium sulfide quantum dots; gold nanoparticles; biosensor; amperometry

资金

  1. Higher Education Commission (HEC) of Pakistan [I-8/HEC/HRD/2017/7726]
  2. DFG within the framework of its Excellence Initiative for the Cluster of Excellence Engineering of Advanced Materials [750302]

向作者/读者索取更多资源

A hybrid nanostructure electrode based on Au/CdS QDs/TNTs was fabricated for nonenzymatic detection of cholesterol and hydrogen peroxide, showing enhanced sensitivity and selectivity. The biosensor demonstrated good reproducibility and thermal stability, with promising potential for enzyme-free biosensing applications.
A thin layer of gold nanoparticles (Au NPs) sputtered on cadmium sulfide quantum dots (CdS QDs) decorated anodic titanium dioxide nanotubes (TNTs) (Au/CdS QDs/TNTs) was fabricated and explored for the nonenzymatic detection of cholesterol and hydrogen peroxide (H2O2). Morphological studies of the sensor revealed the formation of uniform nanotubes decorated with a homogeneously dispersed CdS QDs and Au NPs layer. The electrochemical measurements showed an enhanced electrocatalytic performance with a fast electron transfer (similar to 2 s) between the redox centers of each analyte and electrode surface. The hybrid nanostructure (Au/CdS QDs/TNTs) electrode exhibited about a 6fold increase in sensitivity for both cholesterol (10,790 mu A mM(-1) cm(-2)) and H2O2 (78,833 mu A mM(-1) cm(-2)) in analyses compared to the pristine samples. The hybrid electrode utilized different operational potentials for both analytes, which may lead to a voltage-switchable dual-analyte biosensor with a higher selectivity. The biosensor also demonstrated a good reproducibility, thermal stability, and increased shelf life. In addition, the clinical significance of the biosensor was tested for cholesterol and H2O2 in real blood samples, which showed maximum relative standard deviations of 1.8 and 2.3%, respectively. These results indicate that a Au/CdS QDs/TNTs-based hybrid nanostructure is a promising choice for an enzyme-free biosensor due to its suitable band gap alignment and higher electrocatalytic activities.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据