期刊
CYTOTHERAPY
卷 18, 期 2, 页码 186-197出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2015.10.004
关键词
extracellular matrix; kidney decellularization; kidney recellularization; regenerative medicine; tissue engineering
类别
资金
- National Natural Science Foundation of China [81500665]
- Scientific Research Foundation of Wenzhou, Zhejiang Province, China [H20090014, Y20090269]
- Health Bureau of Zhejiang Province [2010KYB070]
- Research Foundation of Education Bureau of Zhejiang Province [Y201009942]
- Fresh Talent Program for Science and Technology, Wenzhou Medical University [wyx201401011, wyx201401087, wyx201401009, wyx201401085]
- Research Funds for Tian Qing Liver Diseases [TQGB20120057]
- Project of New Century 551 Talent Nurturing in Wenzhou
The prevalence of end-stage renal disease is emerging as a serious worldwide public health problem because of the shortage of donor organs and the need to take lifelong immunosuppressive medication in patients who receive a transplanted kidney. Recently, tissue bioengineering of decellularization and recellularization scaffolds has emerged as a novel strategy for organ regeneration, and we review the critical technologies supporting these methods. We present a summary of factors associated with experimental protocols that may shed light on the future development of kidney bioengineering and we discuss the cell sources and bioreactor techniques applied to the recellularization process. Finally, we review some artificial renal engineering technologies and their future prospects, such as kidney on a chip and the application of three-dimensional and four-dimensional printing in kidney tissue engineering.
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