期刊
FRONTIERS IN NUTRITION
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2020.00159
关键词
triple negative breast cancer; epigenetic regulation; tumor suppressor; DNA methylation; dietary bioactive compounds
资金
- US Department of Defense Breast Cancer Program [BC134119, BC142258]
- Cancer Biology Training Grant [T32CA009213]
- Arizona Cancer Center CROC Pilot Project [P30CA023074]
- USDA-NIFA [ARZT-1370460-R23-155]
Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.
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