期刊
CYTOSKELETON
卷 73, 期 9, 页码 435-441出版社
WILEY-BLACKWELL
DOI: 10.1002/cm.21280
关键词
dendritic spines; actin cytoskeleton; neuronal maturation; synaptic plasticity
类别
资金
- Academy of Finland [SA 266351]
The majority of the postsynaptic terminals of excitatory synapses in the central nervous system exist on small bulbous structures on dendrites known as dendritic spines. The actin cytoskeleton is a structural element underlying the proper development and morphology of dendritic spines. Synaptic activity patterns rapidly change actin dynamics, leading to morphological changes in dendritic spines. In this mini-review, we will discuss recent findings on neuronal maturation and synaptic plasticity-induced changes in the dendritic spine actin cytoskeleton. We propose that actin dynamics in dendritic spines decrease through actin filament crosslinking during neuronal maturation. In long-term potentiation, we evaluate the model of fast breakdown of actin filaments through severing and rebuilding through polymerization and later stabilization through crosslinking. We will discuss the role of Ca2+ in long-term depression, and suggest that actin filaments are dissolved through actin filament severing. (C) 2016 Wiley Periodicals, Inc.
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