期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 27, 期 -, 页码 65-79出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2015.12.005
关键词
Bone morphogenetic proteins (BMP); Signaling; Vasculature; Development; Disease
资金
- Dutch Arthritis Association (Reumafonds)
- excellence cluster REBIRTH
- DFG [SE 2016/8-1]
- INSERM
- CEA
- Universite Grenoble-Alpes (UGA)
- Association pour la Recherche sur le Cancer
- Ligue Contre le Cancer de la Loire et de la Savoie
- Association Maladie de Rendu-Osler (AMRO)
- [FWO-VG.0542.13]
- [GOA011 /012]
The vascular system is critical for developmental growth, tissue homeostasis and repair but also for tumor development. Bone morphogenetic protein (BMP) signaling has recently emerged as a fundamental pathway of the endothelium by regulating cardiovascular and lymphatic development and by being causative for several vascular dysfunctions. Two vascular disorders have been directly linked to impaired BMP signaling: pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling critically depends on the cellular context, which includes among others vascular heterogeneity, exposure to flow, and the intertwining with other signaling cascades (Notch, WNT, Hippo and hypoxia). The purpose of this review is to highlight the most recent findings illustrating the clear need for reconsidering the role of BMPs in vascular biology. (C) 2015 Elsevier Ltd. All rights reserved.
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