期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 28, 期 -, 页码 79-93出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2015.12.001
关键词
Protease; Elastase; Inflammation; Autoimmunity; Allergy
资金
- Polish National Science Center [2011/02/A/NZ5/00337]
- European Union [POIG.02.01.00-12-064/08]
- Polish Ministry of Science and Higher Education
Secretory leukocyte protease inhibitor (SLPI), a similar to 12 kDa nonglycosylated cationic protein, is emerging as an important regulator of innate and adaptive immunity and as a component of tissue regenerative programs. First described as an inhibitor of serine proteases such as neutrophil elastase, this protein is increasingly recognized as a molecule that benefits the host via its anti-proteolytic, anti-microbial and immunomodulatory activities. Here, we discuss the diverse functions of SLPI. Moreover, we review several novel layers of SLPI-mediated control that protect the host from excessive/dysregulated inflammation typical of infectious, allergic and autoinflammatory diseases and that support healing responses through affecting cell proliferation, differentiation and apoptosis. (C) 2015 Elsevier Ltd. All rights reserved.
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