期刊
CYTOKINE
卷 82, 期 -, 页码 4-15出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2016.02.006
关键词
Cytokine; Chronic viral infection; Exhaustion; T cell
资金
- Canadian Institutes of Health Research - Canada
- National Institutes of Health - United States
- Cole Foundation - Canada
- Fonds de Recherche du Quebec - Sante - Canada
- Canadian Child Health Clinician Scientist Program - Canada
- American Association of Immunologists - United States
Intracellular pathogens such as the human immunodeficiency virus, hepatitis C and B or Epstein-Barr virus often cause chronic viral infections in humans. Persistence of these viruses in the host is associated with a dramatic loss of T-cell immune response due to functional T-cell exhaustion. Developing efficient immunotherapeutic approaches to prevent viral persistence and/or to restore a highly functional T-cell mediated immunity remains a major challenge. During the last two decades, numerous studies aimed to identify relevant host-derived factors that could be modulated to achieve this goal. In this review, we focus on recent advances in our understanding of the role of cytokines in preventing or facilitating viral persistence. We concentrate on the impact of multiple relevant cytokines in T-cell dependent immune response to chronic viral infection and the potential for using cytokines as therapeutic agents in mice and humans. (C) 2016 Elsevier Ltd. All rights reserved.
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