期刊
CYTOKINE
卷 83, 期 -, 页码 245-249出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2016.05.007
关键词
Megakaryocyte; TLR2; Wnt/beta-catenin; IL-6; FZD4
资金
- Department of Science & Technology (DST) of Government of India
- Department of Biotechnology (DBT) of Government of India
- Indian Council of Medical Research (ICMR) of Government of India
- Council for Scientific and Industrial Research (CSIR) from Government of India
- University Grants Commission (UGC) from Government of India
TLR2 is a toll-like receptor protein which is involved in innate immune responses. TLR2 recognize several virus, fungal and bacterial pathogens, upon their uptake cause internalization and cellular activation. During this process several cytokines participate including interleukins, IL6 and IL12. Interestingly, TLR2 is expressed on megakaryocytes (MKs) and platelets, which is crucial for immune mediated platelet activation. The role of TLR2 on MKs is not completely understood. We observed TLR2 induction leads to MM maturation and is involved in production of ROS which is essential for MM development. In Dami cells, TLR2 up -regulation causes increase in the cytokine production, particularly IL-6, which has been shown to stimulate CFU formation and CD41 expression. Additionally, TLR2 ligand induces wnt beta-catenin signalling pathway components suggesting a cross talk between wnt and TLR pathway leading to maturation of MKs. This study shows TLR2 signalling induce cytokine production and regulate wnt signalling thereby cause maturation of MKs. (C) 2016 Elsevier Ltd. All rights reserved.
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