期刊
ANTIBIOTICS-BASEL
卷 9, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics9090533
关键词
ribes nigrum; ribes rubrum; rubus idaeus; vaccinium macrocarpon; chlorhexidine; antibacterial agents; cytotoxicity; oral plaque bacteria; periodontitis
(1) Background: Antimicrobial agents such as chlorhexidine (CHX) are commonly used in oral plaque control. However, sometimes those agents lack antimicrobial efficiency or cause undesired side effects. To identify alternative anti-infective agents, the present study investigated the antibacterial activity of all-fruit juices derived from blackcurrant, redcurrant, cranberry and raspberry on common oral pathogenic gram-positive and gram-negative bacteria (Streptococcus mutans,Streptococcus gordonii,Streptococcus sobrinus,Actinomyces naeslundii,Fusobacterium nucleatum,Aggregatibacter actinomycetemcomitans,Porphyromonas gingivalis,Enterococcus faecalis). (2) Methods: Antibacterial efficiency was evaluated by agar diffusion assay and in direct contact with bacteria in planktonic culture. Furthermore, cytotoxicity on human gingival fibroblasts was determined. (3) Results: Blackcurrant juice was most efficient at suppressing bacteria; followed by the activity of redcurrant and cranberry juice. Raspberry juice only suppressedP. gingivalissignificantly. Only high-concentrated blackcurrant juice showed minimal cytotoxic effects which were significantly less compared to the action of CHX. (4) Conclusion: Extracts from natural berry juices might be used for safe and efficient suppression of oral pathogenic bacterial species.
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