期刊
CYTOKINE
卷 82, 期 -, 页码 102-111出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2016.01.020
关键词
Interleukin-15; NAFLD; Mice; Liver; Inflammation
资金
- CIHR
- Faculty of Medicine
Interleukin-15 (IL-15) is essential for the homeostasis of lymphoid cells particularly memory CD8(+) T cells and NK cells. These cells are abundant in the liver, and are implicated in obesity-associated pathogenic processes. Here we characterized obesity-associated metabolic and cellular changes in the liver of mice lacking IL-15 or IL-15R alpha. High fat diet-induced accumulation of lipids was diminished in the livers of mice deficient for IL-15 or IL-15R alpha. Expression of enzymes involved in the transport of lipids in the liver showed modest differences. More strikingly, the liver tissues of IL15-KO and IL15R alpha-KO mice showed decreased expression of chemokines CCI2, CCL5 and CXCL10 and reduced infiltration of mononuclear cells. In vitro, IL-15 stimulation induced chemokine gene expression in wildtype hepatocytes, but not in IL15R alpha-deficient hepatocytes. Our results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease. (C) 2016 Elsevier Ltd. All rights reserved.
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