期刊
METABOLITES
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/metabo10100394
关键词
molecular chaperones; heat shock proteins; environmental stress; immune responses; immunometabolism; epigenetics
资金
- Cancer Research Institute CLIP Investigator Award
- VeloSano Pilot Award
- Case Comprehensive Cancer Center American Cancer Society Pilot Grants
- Cleveland Digestive Diseases Research Core Center Pilot Grant [IRG-91-022-19, IRG-16-186-21, 1P30DK097948]
- Immunology T32 Training Program [AI089474]
Molecular chaperones are a set of conserved proteins that have evolved to assist the folding of many newly synthesized proteins by preventing their misfolding under conditions such as elevated temperatures, hypoxia, acidosis and nutrient deprivation. Molecular chaperones belong to the heat shock protein (HSP) family. They have been identified as important participants in immune functions including antigen presentation, immunostimulation and immunomodulation, and play crucial roles in metabolic rewiring and epigenetic circuits. Growing evidence has accumulated to indicate that metabolic pathways and their metabolites influence the function of immune cells and can alter transcriptional activity through epigenetic modification of (de)methylation and (de)acetylation. However, whether molecular chaperones can regulate metabolic programs to influence immune activity is still largely unclear. In this review, we discuss the available data on the biological function of molecular chaperones to immune responses during inflammation, with a specific focus on the interplay between molecular chaperones and metabolic pathways that drive immune cell fate and function.
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