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Necroptosis in Intestinal Inflammation and Cancer: New Concepts and Therapeutic Perspectives

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ABIN3 Negatively Regulates Necroptosis-induced Intestinal Inflammation Through Recruiting A20 and Restricting the Ubiquitination of RIPK3 in Inflammatory Bowel Disease

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Summary: This study found that excessive necroptosis plays an important role in uncontrolled inflammation and intestinal barrier defects in IBD and experimental colitis. ABIN3 regulates inflammatory response and intestinal barrier function by interacting with A20 and coordinating the K63 deubiquitination modification of necroptosis.

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