期刊
BIOMOLECULES
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/biom10101414
关键词
RVO; oxidative stress; SIRT1; vascular endothelial growth factor; VEGF
资金
- Taipei Veterans General Hospital, Taipei, Taiwan [V103C-166, V104C-175, V104E14-003-MY3-2, V105C-189]
- Ministry of Science and Technology of Taiwan Columbus program of MOST Young Scholar Fellowship, Taipei, Taiwan [106-2314-B-075A-001, 107-2221-E-040-010, 109-2636-E-040-001]
- Research Foundation of Cardiovascular Medicine, Taipei, Taiwan [100-01-010]
Objectives: Retinal vein occlusions (RVO) are associated with systemic risk factors. However, the ocular occlusive events might also influence a patient's systemic condition. This study tried to investigate serum biomarkers associated with oxidative stress, before and after intravitreal anti-vascular endothelial growth factor (aVEGF) therapy in patients with RVOs. Methods: Newly-onset RVO patients were categorized into two groups: comorbid with macular edema requiring aVEGF therapy (treatment group) and no edema (observation group). Age and sex-matched patients (who received cataract surgery) were included as the control group. Intravitreal ranibizumab with a pro-re-nata regimen were administered. Serum samples were collected prior to treatment, at 6 and 12 months after therapy/observation and were collected once before controls who received cataract surgery. mRNA expression of sirtuin-1, its downstream genes, anti-oxidative biomarkers, and proinflammatory cytokines were measured. Results: There were 32, 26, and 34 patients enrolled in the treatment, observation, and control groups, respectively. The expressions of sirtuin-1 and its downstream genes were significantly lower in patients with RVO compared with the control group. Sirtuin-1 gene expression increased after 1 year of aVEGF therapy in the treatment group but remained unchanged in the observation group. Biomarkers of oxidative stress and proinflammatory cytokines were reduced after 1 year of aVEGF therapy. These biomarkers remained with no changes in the observation group. Conclusions: Our study showed that the systemic oxidative stress increased in RVO patients. The aVEGF therapy could alter the gene expression of anti-oxidative proteins and reduce systemic oxidative stress in these patients.
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