期刊
VACCINES
卷 8, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/vaccines8040585
关键词
African swine fever; ASFV; genome packaging; viral DNA-packaging proteins; NCLDV; vaccine; antiviral therapy; stilbenes; pA104R
资金
- Fundacao para a Ciencia e a Tecnologia (Portugal) [CIISA-UIDP/CVT/00276/2020]
- European Project H2020 VACDIVA-A Safe DIVA vaccine for African Swine Fever control and eradication [862874]
The recent incursions of African swine fever (ASF), a severe, highly contagious, transboundary viral disease that affects members of the Suidae family, in Europe and China have had a catastrophic impact on trade and pig production, with serious implications for global food security. Despite efforts made over past decades, there is no vaccine or treatment available for preventing and controlling the ASF virus (ASFV) infection, and there is an urgent need to develop novel strategies. Genome condensation and packaging are essential processes in the life cycle of viruses. The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. pA104R is a highly conserved HU/IHF-like DNA-packaging protein identified in the ASFV nucleoid that appears to be profoundly involved in the spatial organization and packaging of the ASFV genome. Here, we briefly review the components of the ASFV packaging machinery, the structure, function, and phylogeny of pA104R, and its potential as a target for vaccine and drug development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据