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T cell antigen receptor signaling and immunological synapse stability require myosin IIA
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NATURE IMMUNOLOGY (2009)
Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion
Thomas S. van Zanten et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Hunter to Gatherer and Back: Immunological Synapses and Kinapses as Variations on the Theme of Amoeboid Locomotion
Michael L. Dustin
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2008)
STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER
Ilya Grigoriev et al.
CURRENT BIOLOGY (2008)
Tyrosine-Phosphorylation-Dependent Translocation of the SLAT Protein to the Immunological Synapse Is Required for NFAT Transcription Factor Activation
Stephane Becart et al.
IMMUNITY (2008)
T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76
Ken Nguyen et al.
IMMUNITY (2008)
Regulation of T cell integrin function by adapter proteins
Rebecca G. Baker et al.
IMMUNOLOGIC RESEARCH (2008)
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation
Genaro Patino-Lopez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
MTOC translocation modulates IS formation and controls sustained T cell signaling
Noa B. Martin-Cofreces et al.
JOURNAL OF CELL BIOLOGY (2008)
An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes
Olga Anton et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA
Yuan-Chen Chang et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
Aubin Penna et al.
NATURE (2008)
Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner
Colin K. Choi et al.
NATURE CELL BIOLOGY (2008)
Human immunodeficiency virus type 1 nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity
Susanne Rauch et al.
JOURNAL OF VIROLOGY (2008)
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
Oreste Acuto et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells
Yoshihisa Kaizuka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
c-Cbl-mediated regulation of LAT-nucleated signaling complexes
Lakshmi Balagopalan et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins
Antonella Viola et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Cutting edge: Atypical PKCs regulate T lymphocyte polarity and scanning behavior
Eliana Real et al.
JOURNAL OF IMMUNOLOGY (2007)
Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
Dimitris Skokos et al.
NATURE IMMUNOLOGY (2007)
TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation
Jeffrey C. Nolz et al.
JOURNAL OF IMMUNOLOGY (2007)
Opposing effects of PKCθ and WASp on symmetry breaking and relocation of the immunological synapse
Tasha N. Sims et al.
CELL (2007)
Regulated binding of adenomatous polyposis coli protein to actin
James B. Moseley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors
June L. Round et al.
NATURE IMMUNOLOGY (2007)
Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse
Timothy S. Gomez et al.
IMMUNITY (2007)
Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT
Gerardo G. Mackenzie et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Modulation of the immunological synapse: a key to HIV-1 pathogenesis?
Oliver T. Fackler et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton
Bjorn F. Lillemeier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Maintenance and modulation of T cell polarity
Matthew F. Krummel et al.
NATURE IMMUNOLOGY (2006)
Recruitment of dynein to the Jurkat immunological synapse
Jeffrey Combs et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Centrosome polarization delivers secretory granules to the immunological synapse
Jane C. Stinchcombe et al.
NATURE (2006)
Orai1 is an essential pore subunit of the CRAC channel
Murali Prakriya et al.
NATURE (2006)
The kinetic-segregation model: TCR triggering and beyond
Simon J. Davis et al.
NATURE IMMUNOLOGY (2006)
Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering
Christopher W. Cairo et al.
IMMUNITY (2006)
FOXP3 controls regulatory T cell function through cooperation with NFAT
Yongqing Wu et al.
CELL (2006)
Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses
Aurelie Wiedemann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-wasp activity
Claudia Haller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
Rajat Varma et al.
IMMUNITY (2006)
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse
Timothy S. Gomez et al.
IMMUNITY (2006)
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
Yousang Gwack et al.
NATURE (2006)
Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
Maria Isabel Thoulouze et al.
IMMUNITY (2006)
Ca2+ shuttling between endoplasmic reticulum and mitochondria underlying Ca2+ oscillations
K Ishii et al.
EMBO REPORTS (2006)
T cells use two directionally distinct pathways for cytokine secretion
M Huse et al.
NATURE IMMUNOLOGY (2006)
Vimentin function in lymphocyte adhesion and transcellular migration
M Nieminen et al.
NATURE CELL BIOLOGY (2006)
The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation
JC Nolz et al.
CURRENT BIOLOGY (2006)
Lipid rafts in lymphocyte activation and migration (Review)
S Manes et al.
MOLECULAR MEMBRANE BIOLOGY (2006)
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
T Yokosuka et al.
NATURE IMMUNOLOGY (2005)
Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the αL/β2 integrin, LFA-1, during leukocyte chemotaxis
M Fabbri et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Altered TCR signaling from geometrically repatterned immunological synapses
KD Mossman et al.
SCIENCE (2005)
CD4 T cells integrate signals delivered during successive DC encounters in vivo
S Celli et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Cutting edge:: Cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells
JP O'Keefe et al.
JOURNAL OF IMMUNOLOGY (2005)
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
G Campi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
SYL Zhang et al.
NATURE (2005)
Loss of adenomatous polyposis coli gene function disrupts thymic development
F Gounari et al.
NATURE IMMUNOLOGY (2005)
A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes
A Smith et al.
JOURNAL OF CELL BIOLOGY (2005)
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation
MJ Ludford-Menting et al.
IMMUNITY (2005)
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
EJ Ezratty et al.
NATURE CELL BIOLOGY (2005)
Structural basis of Rho GTPase-mediated activation of the formin rnDia1
T Otomo et al.
MOLECULAR CELL (2005)
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering
BH Luo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
TS Gomez et al.
NATURE IMMUNOLOGY (2005)
Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells
JL Round et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Immunological synapses are versatile structures enabling selective T cell polarization
D Depoil et al.
IMMUNITY (2005)
Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse: Involvement of SNARE complexes
V Das et al.
IMMUNITY (2004)
Membranes as messengers in T cell adhesion signaling
ML Dustin et al.
NATURE IMMUNOLOGY (2004)
Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment
G Bonello et al.
JOURNAL OF CELL SCIENCE (2004)
ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation
S Faure et al.
NATURE IMMUNOLOGY (2004)
Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1
T Wittmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation
MM Gorska et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Role of the cytoskeleton during leukocyte responses
M Vicente-Manzanares et al.
NATURE REVIEWS IMMUNOLOGY (2004)
Clustering induces a lateral redistribution of α2β1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization
P Upla et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration
FV Rivas et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Strong and durable TCR clustering at the T/dendritic cell immune synapse is not required for NFAT activation and IFN-γ production in human CD4+ T cells
N Blanchard et al.
JOURNAL OF IMMUNOLOGY (2004)
Role of NFAT proteins in IL13 gene transcription in mast cells
S Monticelli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2
M Kim et al.
JOURNAL OF CELL BIOLOGY (2004)
Discs large (DIg1) complexes in lymphocyte activation
R Xavier et al.
JOURNAL OF CELL BIOLOGY (2004)
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
T Watanabe et al.
DEVELOPMENTAL CELL (2004)
Cutting edge:: Selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells
V Morales-Tirado et al.
JOURNAL OF IMMUNOLOGY (2004)
Actin and microtubules in cell motility: Which one is in control?
S Etienne-Manneville
TRAFFIC (2004)
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation
JH Lee et al.
JOURNAL OF CELL BIOLOGY (2004)
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes
R Nijhara et al.
JOURNAL OF IMMUNOLOGY (2004)
T cell killing does not require the formation of a stable mature immunological synapse
MA Purbhoo et al.
NATURE IMMUNOLOGY (2004)
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1
H Okamura et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Cell migration: Integrating signals from front to back
AJ Ridley et al.
SCIENCE (2003)
Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization
MJ Brown et al.
BLOOD (2003)
T-cell integrins: more than just sticking points
N Hogg et al.
JOURNAL OF CELL SCIENCE (2003)
Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction:: Manifestation of a dual activation threshold
M Faroudi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The immunological synapse balances T cell receptor signaling and degradation
KH Lee et al.
SCIENCE (2003)
MAL regulates clathrin-mediated endocytosis at the apical surface of Madin-Darby canine kidney cells
F Martín-Belmonte et al.
JOURNAL OF CELL BIOLOGY (2003)
Transcriptional regulation by calcium, calcineurin, and NFAT
PG Hogan et al.
GENES & DEVELOPMENT (2003)
Linker for activation of T cells, ζ-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization
MR Kuhné et al.
JOURNAL OF IMMUNOLOGY (2003)
Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse
L Ardouin et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
RhoG regulates gene expression and the actin cytoskeleton in lymphocytes
E Vigorito et al.
ONCOGENE (2003)
Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation
LIR Ehrlich et al.
IMMUNITY (2002)
Regulation of constitutive TCR internalization by the ζ-chain
U D'Oro et al.
JOURNAL OF IMMUNOLOGY (2002)
In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern
N Blanchard et al.
IMMUNITY (2002)
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
SC Bunnell et al.
JOURNAL OF CELL BIOLOGY (2002)
TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts
P Drevot et al.
EMBO JOURNAL (2002)
TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex
N Blanchard et al.
JOURNAL OF IMMUNOLOGY (2002)
Identification of a link between the tumour suppressor APC and the kinesin superfamily
T Jimbo et al.
NATURE CELL BIOLOGY (2002)
T cell receptor signaling precedes immunological synapse formation
KH Lee et al.
SCIENCE (2002)
Cutting edge: Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly
K Itoh et al.
JOURNAL OF IMMUNOLOGY (2002)
Dynamic polarization of the microtubule cytoskeleton during CTL-Mediated killing
JR Kuhn et al.
IMMUNITY (2002)
Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1
JL Rodríguez-Fernández et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The immunological synapse of CTL contains a secretory domain and membrane bridges
JC Stinchcombe et al.
IMMUNITY (2001)
The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation
A Roumier et al.
IMMUNITY (2001)
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse
EJ Allenspach et al.
IMMUNITY (2001)
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin
J Delon et al.
IMMUNITY (2001)
Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization
C Gómez-Moutón et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Cbl promotes ubiquitination of the T cell receptor ζ through an adaptor function of Zap-70
HY Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization
M Nakamura et al.
CURRENT BIOLOGY (2001)
Activation of RhoA and ROCK are essential for detachment of migrating Leukocytes
J Alblas et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
A role for Wiskott-Aldrich syndrome protein in T-cell receptor-mediated transcriptional activation independent of actin polymerization
C Silvin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments
MJ Brown et al.
JOURNAL OF IMMUNOLOGY (2001)
Partners in transcription:: NFAT and AP-1
F Macián et al.
ONCOGENE (2001)
CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells
II Singer et al.
JOURNAL OF VIROLOGY (2001)
Dynamic actin polymerization drives T cell receptor-induced spreading: A role for the signal transduction adaptor LAT
SC Bunnell et al.
IMMUNITY (2001)
Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells
T Iida et al.
JOURNAL OF IMMUNOLOGY (2000)
Asef, a link between the tumor suppressor APC and G-protein signaling
Y Kawasaki et al.
SCIENCE (2000)
p21-activated kinase 1 plays a critical role in cellular activation by Nef
OT Fackler et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
H Okamura et al.
MOLECULAR CELL (2000)