期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.562522
关键词
GBA; alpha-synuclein; dementia; GCase; Parkinson
资金
- University of Tubingen
- German Society of Parkinson's Disease (dPV)
- Michael J. Fox Foundation (MJFF)
- German Centre for Neurodegenerative Diseases (DZNE, MIGAP)
- Movement Disorders Society
With disease-modifying compounds targeting alpha-synuclein available in clinical trials, patient stratification according to alpha-synuclein-specific enrichment strategies is a much-needed prerequisite. Such a scenario will be exemplified forGBA, one major genetic risk factor that is specifically associated with the alpha-synucleinopathies: Parkinson's disease and dementia with Lewy bodies.
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