期刊
APPLIED MATERIALS TODAY
卷 20, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apmt.2020.100770
关键词
Bone ingrowth; Additive manufacturing; Bioglass; Bioactive glass; Bone remodelling
资金
- EPSRC [EP/I020861/1]
- Department of Materials (Imperial College London)
- MRC [MR/R025673/1]
- DEL/CAST Award from the University of Ulster
- Royal Academy of Engineering Chair in Emerging Technology
- EPSRC [EP/I020861/1, EP/M022498/1] Funding Source: UKRI
- MRC [MR/R025673/1, MR/L012677/1] Funding Source: UKRI
The architecture of bone scaffolds, such as pore dimensions, connectivity and orientation can regulate osteogenic defect repair, as can their rate of degradation. Synthetic bone grafts have historically been developed with foam structures to mimic trabecular bone. Now, Additive Manufacturing techniques enable production of open and regular pore architectures with improved compressive strengths. Here, we compare two types of bioactive glass scaffolds, made of the highly biodegradable ICIE16 composition, with distinctively different architectures but matched interconnect sizes (similar to 150 mu m), produced via two different techniques: gel-cast foaming and direct ink writing. A rabbit lateral femoral defect model was used to compare the effect of their architecture on in vivo bone regeneration, relative to a defect only control group, after 4 and 10 weeks of implantation. 3D X-ray microcomputed tomography (micro-CT), correlated to histology and back-scatter electron microscopy (BS-SEM) permitted quantitative evaluation of new bone ingrowth and degradation of the scaffolds. Both foam and printed scaffolds showed equal or higher bone ingrowth compared to the control group. After 4 weeks, the foam group showed the highest osteogenesis, with 51% more bone ingrowth than the defect only controls, but after 10 weeks the defect treated with the printed scaffold had the most bone ingrowth (40% more than the empty defect). Energy dispersive X-ray (EDS) mapping revealed degradation of the glass and calcium-phosphate deposition. The foam group showed more rapid degradation than the printed group, due to higher total porosity (even though interconnected pore size was equivalent). The foam scaffold appeared to allow rapid bone ingrowth and cancellous bone formation, whereas the printed scaffold seemed to provoke cortical-like bone formation, while remaining in place for longer than the 10 week study. While the foam's concave architectures promote initial bone ingrowth, the higher strength open pore channels of the printed scaffolds are beneficial for scaffolds made of highly degradable bioactive glasses. (c) 2020 Elsevier Ltd. All rights reserved.
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