期刊
APPLIED MATERIALS TODAY
卷 20, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apmt.2020.100706
关键词
Additive manufacturing; Thermal extrusion; Microscale porosity; Macroporosity; Medical grade polycaprolactone; Bone regeneration
资金
- Central Analytical Research Facility (CARF) and The Medical Engineering Research Facility (MERF) at the Queensland University of Technology
- Australian Research Council under the ARC Training Centre in Additive Biomanufacturing
- National Health, and Medical Research Council
- Queensland University of Technology
- Advance Queensland Research Fellowship
The application of 3D printed scaffolds f or bone tissue regeneration has been explored in previous studies. In this study, we combined 3D printing with porogen leaching to develop scaffolds with dual-scale porosity and investigated their capability in guided bone regeneration in a rat critical size calvarial defect model. The scaffolds were additively manufactured from medical grade polycaprolactone (mPCL) doped with porogen microparticles having an average size of 22 mu m, which were subsequently leached to create microscale porosity. Morphological analysis revealed an interconnected macroscale porosity of about 60% with an average pore size of 700 mu m and intra-strut microscale pores with a porosity of nearly 40% and average pore size of 20-70 mu m. The microscale porosity resulted in a 3-fold increase in the scaffolds' surface area, a 2-fold enrichment in negatively charged surface groups, which did lead to significantly increased protein adsorption and faster hydrolysis-driven degradation in vitro . An in vitro blood clotting assay demonstrated an increased TGF-beta 1 release from the clots formed on the dual-scale porous scaffolds. In a rat calvarial defect, bone formation was found in both the macroand microscale pores and was at a similar level when compared to calcium phosphate coated mPCL scaffolds. Crown Copyright (c) 2020 Published by Elsevier Ltd. All rights reserved.
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