期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 16, 期 11, 页码 1200-1216出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150915111741
关键词
Sulfur containing drugs; Sulfonamide; Thioether; Sulfones; Sulfur dioxide fixation; Organic synthesis
资金
- NBRPC [2015CB856600]
- NSFC [21472050, 21272075]
- NCET [120178]
- DFMEC [20130076110023]
- Fok Ying Tung Education Foundation [141011]
- program for Shanghai Rising Star [15QA1401800]
- Shanghai Institutions of Higher Learning
- Changjiang Scholar and Innovative Research Team in University
- NATIONAL INSTITUTE ON DRUG ABUSE [K01DA038000] Funding Source: NIH RePORTER
The impact of the development of sulfur therapeutics is instrumental to the evolution of the pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of pharmaceuticals and natural products. For centuries, sulfur continues to maintain its status as the dominating heteroatom integrated into a set of 362 sulfur-containing FDA approved drugs (besides oxygen or nitrogen) through the present. Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades. In this review, these four moieties in pharmaceuticals and recent advances in the synthesis of the corresponding core scaffolds are presented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据