期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 16, 期 30, 页码 3569-3581出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026616666160526125352
关键词
Anti-inflammatory agents; Azoles; Imidazoles; Oxadiazoles; Oxazoles; Pyrazoles; Thiazoles; Triazoles
There has been considerable interest in azole-containing compounds as promising anti-inflammatory agents. Designed compounds with five-membered nitrogen-containing nuclei have demonstrated good anti-inflammatory activity, indicating their potential for the treatment of this highly irritating condition. Pyrazoles, have attracted much more attention than other azoles, however, reports on other azoles demonstrated that they were as effective as pyrazoles. This review describes the different classes of azoles designed as cyclooxygenase inhibitors and the effect of different structural modifications on their activity.
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