期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 16, 期 27, 页码 3033-3047出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026616666160216160112
关键词
Melanoma; Tyrosinase; TRP-1; TRP-2; Tyrosinase effectors
资金
- CNRS
- French Agence Nationale pour la Recherche [ANR-09-BLAN-0028-01/02/03]
- Aix-Marseille University
- Labex Arcane [ANR-11-LABX-0003-01]
Among the human copper-containing monooxygenases, Tyrosinase (Ty) is an important enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation into L-DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin production, so their development has a huge economical and industrial impact. Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches, due to the complex biochemical reaction involved in the melanin synthesis.
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